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曲来亮

时间:2023年03月08日 10:26 来源:55net必赢 浏览次数:[]


 


    个人概况

    曲来亮:个人简介

教育经历

201809月至202112  中国药科大学 药学(天然药物化学)专业 博士

201509月至201807  郑州大学 生药学 专业 硕士

201109月至201507  河南中医药大学 中药制药 专业 学士

工作经历

2022.03年至今 信阳师范学院 55net必赢 讲师

研究领域

1抗阿尔茨海默症、抗肿瘤药物的设计、合成及药理作用机制研究 ;

2基于天然产物的合理药物设计与研究

3. 计算机辅助药物设计

工作介绍

1.主讲《医用化学》、《生理学》本科生课程;

2.主要从事基于天然产物的抗阿尔茨海默症、抗肿瘤药物的设计合成,通过合理药物设计和计算机辅助药物设计相结合,发现具有开发价值的创新性药物;

主持科研项目

1信阳师范学院博士科研启动基金项目,10万元,在研,主持。

发表高层次论文

1Lailiang Qu, …, Lingyi Kong*, Xiaobing Wang*. Synthesis and Evaluation of Multi-Target-Directed Ligands with BACE-1 Inhibitory and Nrf2 Agonist Activities as Potential Agents against Alzheimer's Disease. European Journal of Medicinal Chemistry, 219 (2021) 113441.

2Lailiang Qu, …, Lingyi Kong*, Xiaobing Wang*. Discovery of PT-65 as a Highly Potent and Selective Proteolysis-Targeting Chimera Degrader of GSK3 for Treating Alzheimer’s Disease. European Journal of Medicinal Chemistry, 226 (2021) 113889.

3Lailiang Qu, …, Yong Guo*. Application of Sustainable Natural Bioresources in Agriculture: Iodine-Mediated Oxidative Cyclization for Metal-Free One-Pot Synthesis of N-Phenylpyrazole Sarisan Analogues as Insecticidal Agents. ACS Omega, 2017, 2, 9, 5974–5980.

4Shang Li, Lailiang Qu, Xiaobing Wang*, Lingyi Kong*, Novel insights into RIPK1 as a promising target for future Alzheimer’s disease treatment. Pharmacology & Therapeutics, 2021, 107979.

5Cheng Wang, Lailiang Qu, …, Lingyi Kong*, and Xiaobing Wang*, Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA, Journal of Medicinal Chemistry, 2021, 64: 12630-12650.

6Limei Ji, Lailiang Qu, …, Lingyi Kong*, Xiaobing Wang*. Identification and optimization of Piperlongumine analogues as potential antioxidant and anti-inflammatory agents via activation of Nrf2. European Journal of Medicinal Chemistry, 210 (2021) 112965.

7Yong Guo*, Lailiang Qu, …, Yanbing Zhang*. Iodine-catalyzed oxidative cyclisation for the synthesis of sarisan analogues containing 1,3,4-oxadiazole as insecticidal agents, RSC Advances, 2016. 6. 93505-93510.

联系方式:邮箱:qulailiang@126.com;办公室:行政楼126

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